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VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:National Nanomedicine Seminar - "Nanoparticle Development to T
 arget Dysfunctional Endothelial Glycocalyx"
X-WR-TIMEZONE:Eastern Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260916T162544Z
UID:tag:localist.com\,2008:EventInstance_4447811
DTSTART:20190326T192500Z
DTEND:20190326T202500Z
DESCRIPTION:Eno Ebong\, PhD\nAssistant Professor\, Chemical Engineering\, N
 ortheastern University\n\n \n\nNanoparticle Development to Target Dysfunct
 ional Endothelial Glycocalyx\n\nThe Ebong research lab studies how the mec
 hanical forces of blood flow affect endothelial cells\, which line the blo
 od vessels and guard them from diseases like atherosclerosis—a pre­curs
 or to heart attack and other serious conditions. Much of the focus is on s
 tudying the structure and function of the protective gel-like layer of sug
 ar molecules and proteins coating the surface of the endothelial cells—c
 alled the glycocalyx—to understand\, on a molecular level\, how mechanob
 iology remodels the endothelial cells to facilitate protection from diseas
 e. This glycocalyx struc­ture gives fragile arteries the resilience they 
 need to with­stand the rau­cous fluid envi­ron­ment coursing through t
 hem\, espe­cially at the branch points where plaques are most prevalent. 
 Glycocalyx sheds in the presence of atherosclerosis\, so it is of great in
 terest to study how gradual glycocalyx degradation initiates and/or promot
 es pathological remodeling that forms atherosclerotic lesions. The Ebong l
 ab constructs in vitro systems comprising fluids and mammalian endothelial
  cells\, to replicate both healthy and disruptive blood-flow conditions an
 d to uncover the intricacies of the flow-glycocalyx-endothelial cell relat
 ionship. This work is combined with live animal studies to assess the vali
 dity of the findings\, in real disease conditions. The long term goal is t
 o leverage mechanobiology\, endothelial cells\, and the glycocalyx to deve
 lop nanomedicine-based therapies that reverse the progression of atheroscl
 erosis.\n\nDr. Eno Essien Ebong earned her S.B. (1999) in Mechanical Engin
 eering from the Massachusetts Institute of Technology in Boston\, MA in 19
 99 and her M.Eng (2001) and Ph.D. (2006) in the area of biomechanics from 
 the Department of Biomedical Engineering at Rensselaer Polytechnic Institu
 te in Troy\, NY. She was a National Institutes of Health Cardiovascular Re
 search Fellow (2007 to 2012) at the Albert Einstein College of Medicine in
  New York\, NY. Currently\, Dr. Ebong is an Assistant Professor in the Dep
 artments of Chemical Engineering and Bioengineering at Northeastern Univer
 sity. She is a recent recipient of the prestigious NSF CAREER Award\, for 
 her “EMBRACE STEM (Endothelial MechanoBiology Research And multiCultural
  Education in STEM)” project. She has also been award the NIH Mentored R
 esearch Career Development Award (K01)\, for studying "Atheroprotective vs
 . Atherogenic Glycocalyx Mechanotransduction Mechanisms."
LOCATION:119 Snell Library
SUMMARY:National Nanomedicine Seminar - "Nanoparticle Development to Target
  Dysfunctional Endothelial Glycocalyx"
URL;VALUE=URI:https://calendar.northeastern.edu/event/national_nanomedicine
 _seminar_-_nanoparticle_development_to_target_dysfunctional_endothelial_gl
 ycocalyx
CATEGORIES:Seminar
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