MIE Seminar Presentation: Tackling skeletal diseases: an integrated approach
~~ The Department of Mechanical and Industrial Engineering Presents
Dr. Amir A. Zadpoor
Assistant Professor in the Department of Biomechanical Engineering, Delft University of Technology (TU Delft)
Topic: Tackling skeletal diseases: an integrated approach
Date: Tuesday, April 8, 2014
Time: 10:00am to 12:00pm (Refreshments from 9:30am to 10:00am)
Location: 440 Curry Student Center
Abstract: Musculoskeletal diseases present increasingly important challenges to our aging societies. Many old problems such as osteoarthritis, bony tissue non-unions, and tendinopathy remain stubbornly unsolved. Several new technologies have been introduced during the last decades to improve the diagnosis and treatment of skeletal diseases. However, the clinical impact of the introduced technologies has been limited so far. In an integrated translational approach, orthopedic biomechanics is combined with image processing, human movement science, biomaterials, regenerative medicine, and controlled drug delivery to improve the diagnosis and treatment of skeletal diseases. The principal assumption behind the integrated approach is that integrating multiple techniques and taking advantage of the resulting synergy is an important translational step in development of clinically applicable solutions and could maximize clinical impact. In this talk, two concrete examples of integrated solutions from my current research projects are presented. In the first example, the development of an automated finite element modeling platform for analysis of the upper-extremity bones is described. The platform combines patient-specific finite element models with patient-specific musculoskeletal models, advanced image processing and meshing techniques, and statistical shape and appearance models for efficient computational study of the upper-extremity orthopaedic problems. The results of three studies using the developed platform will be briefly presented including a study on the scapula bone tissue adaptation, a study on the loosening of implanted shoulder joints, and a Monte-Carlo study of uncertainties in patient-specific finite element modeling of the scapula. In the second example, different variations of porous titanium bone substitutes are presented where bio-fabrication is combined with mechanical design, surface treatment, controlled drug release, and regenerative medicine to regenerate bone in segmental bone defects.
Brief bio: Dr. Amir A Zadpoor is working as an Assistant Professor in the Department of Biomechanical Engineering, Delft University of Technology (TU Delft). His current research interests include orthopaedic biomechanics, orthopaedic biomaterials, bio-fabrication, skeletal imaging, and mechanobiology. Amir obtained his PhD (cum laude) from TU Delft where he worked at the intersection of solid mechanics and material science. Amir’s prior education included an MSc in Biomedical Engineering and a BSc in Mechanical Engineering. He has published 55 papers in international archival journals (H-index: 16), is serving on the editorial boards of several journals, has organized several international meetings, and has reviewed for more than 30 journals.
Tuesday, April 8, 2014 at 10:00am to 12:00pm
Curry Student Center, 440
346 Huntington Avenue, Boston, MA, Boston